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  • Stevens KN, Croes S, Boersma RS, Stobberingh EE, van der Marel C, van der Veen FH, Knetsch ML, Koole LH. Hydrophilic surface coatings with embedded biocidal silver nanoparticles and sodium heparin for central venous catheters. Biomaterials. 2011 Feb;32(5):1264-9. Epub 2010 Nov 19.
  • Stevens KN, Knetsch ML, Sen A, Sambhy V, Koole LH. Disruption and activation of blood platelets in contact with an antimicrobial composite coating consisting of a pyridinium polymer and AgBr nanoparticles. ACS Appl Mater Interfaces. 2009 Sep;1(9):2049-54.
  • Stevens KN, Crespo-Biel O, van den Bosch EE, Dias AA, Knetsch ML, Aldenhoff YB, van der Veen FH, Maessen JG, Stobberingh EE, Koole LH. The relationship between the antimicrobial effect of catheter coatings containing silver nanoparticles and the coagulation of contacting blood. Biomaterials. 2009 Aug;30(22):3682-90. Epub 2009 Apr 26.
  • Stevens KN, Aldenhoff YB, van der Veen FH, Maessen JG, Koole LH. Bioengineering of improved biomaterials coatings for extracorporeal circulation requires extended observation of blood-biomaterial interaction under flow. J Biomed Biotechnol. 2007;2007(10):29464
  • Aldenhoff YBJ, Hanssen HHL, Knetsch MLW, Koole LH. Thrombus Formation at the Surface of Guide-Wire Models: Effects of Heparin-releasing or Heparin-exposing Surface Coatings. J Vasc Interv Radiol. 2007 Mar;18(3):419-25.
  • Peerlings CCL, Hanssen HHL, Bevers RTJ, Boelen EHJ, Stelt BJ, Korthagen EJM and Koole LH. Heparin release from slippery-when-wet guide wires for intravascular use. J Biomed Mater Res: Appl Biomaterials, 2002;63:692-698.
  • Hanssen HJ and Koole LH. Heparin-releasing intravascular guidewires. Med Device Technol. 2002;13(7):20-2.
  • Hanssen JHL, Wetzels GMR, Benzina A, van der Veen FH, Lindhout T, and Koole LH. Metallic wires with an adherent lubricious and blood-compatible polymeric coating and their use in the manufacture of novel slippery-when-wet guidewires. Possible applications related to controlled local drug delivery. J Biomed Mater Res: Appl. Biomaterials, 1999;48:820-828.




Biomacromolecules. 2010 Dec 13;11(12):3556-62. doi: 10.1021/bm1010273. Epub 2010 Oct 20.

Versatile polymer microspheres for injection therapy: aspects of fluoroscopic traceability and biofunctionalization.

Saralidze K, Knetsch ML, van der Marel C, Koole LH.


Department of Biomedical Engineering/Biomaterials Sciences, Faculty of Health, Medicine, and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands. k.saralidze@bioch.unimaas.nl


Synthesis and characterization of a series of novel microspheres featuring (i) radiopacity (i.e., clear fluoroscopic traceability) and (ii) an outer surface exposing aldehyde groups are reported. The aldehydes allowed us to tether proteins onto the particles’ surface under mild conditions, under which the protein conformation and, hence, structural motifs for biorecognition are preserved. Essential monomer building blocks were (i) 4-iodobenzoyl-2-oxo-ethylmethacrylate (4-IEMA) for radiopacity and (ii) propenal for surface tethering of proteins. The particles demonstrated good X-ray visibility and cytocompatibility. Procedures to couple proteins onto the surface were optimized using fluorescent bovine serum albumin (FITC-BSA) or collagen (FITC-collagen). Furthermore, radiopaque microparticles with unlabeled bovine collagen type I were produced. The presence of immobilized collagen was verified with narrow-scan X-ray photoelectron spectroscopy. Fibroblasts readily adhere to and grow on the collagen-modified surfaces, whereas this was much less the case for the unmodified controls. The results led us to suggest that immobilized nondenatured collagen may transform filler particles from passive space-occupying objects to particles that cross-talk with surrounding tissues.

PMID: 20961118 [PubMed – indexed for MEDLINE]




Ratio NVP/BMA State Product number
90/10 Granules 920100
Granulate 920101
Solution 920102
70/30 Granules 920110
Granulate 920111
Solution 920112
50/50 Granules 920120
Granulate 920121
Solution 920122
30/70 Granules 920130
Granulate 920131
Solution 920132
10/90 Granules 920140
Granulate 920141
Solution 920142
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