iNephron – Wearable Artificial Kidney

Development of novel membranes for blood purification therapies based on copolymers of N-vinylpyrrolidone and n-butylmethacrylate
 

Authors: M. Tijink, J. Janssen, M. Timmer, J. Austen, Y. Aldenhoff, J. Kooman, L. Koole, J. Damoiseaux, R. van Oerle, Y. Henskens, D. Stamatialis

Keywords: blood purification; plasma separation membranes; copolymer N-vinylpyrrolidone and butylmethacrylate (BMA); blood biocompatibility

Abstract

Developments in membrane based blood purification therapies often come with longer treatment times and therefore longer blood-material contact, which requires long-term membrane biocompatibility. In this study, we develop for the first time membranes for blood purification using the material SlipSkin™, which is a copolymer, made from N- vinylpyrrolidone (NVP) and butylmethacrylate (BMA). Specific attention is focused on understanding the mechanism of pore formation and the tailoring of the membrane mechanical and transport properties to obtain the optimal membrane for blood purification therapies. Polymer composition, solvent type and solvent evaporation time influence membrane morphology and membranes with sieving properties of cascade filters in plasma fractionation applications are developed. The new membranes have very good blood compatibility properties; in fact compared to benchmark flat membranes currently used in the clinic, they have lower platelet adhesion while all other properties (contact activation, thrombogenicity, leukocyte adhesion, hemolysis and complement activation) are also very good and comparable to the benchmarks.

Journal of Materials Chemistry B, 2013, 1, 6066-6077, accepted manuscript. DOI: 10.1039/C3TB20964D. 

  • Latest news:

    February 2015:

    PMLF laboratory technology/biotechnology accreditation

     

    February 2014:

    INterface BIOmaterials BV participates in the LSH impuls project: “KidneyPort

     

    August 2013:

    PMLF laboratory technology accreditation

     

    July 2013:

    PMLF process engineering accreditation

     

    February 2013:

    CE certification on X-Spheres™

     

    November 2012:

    ISO 13485 certification

     

    January 2011:

    INterface BIOmaterials BV participates in the Interreg IVa project: “BioMiMedics”

     

    January 2010:

    INterface BIOmaterials BV participates in the “iNephron” project subsidized by the Dutch Kidney Foundation